Proteases, Extracellular Matrix, and Cancer
نویسندگان
چکیده
منابع مشابه
Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research.
Our view of the ECM and its role in cancer has substantially evolved over the last decade. It is now apparent that the ECM is much more than a physical barrier against tumor invasion. It is an integral part of the tumor microenvironment and extensively modified by proteases during malignant progression. We have begun to appreciate that these proteases do more than just degrade the ECM and allow...
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Cancer metastasis remains the most poorly understood process in cancer biology. It involves the degradation of extracellular matrix (ECM) proteins by a series of 'tumour-associated' proteases. Here we report the identification of a novel protease suppressor, NYD-SP8, which is located on human chromosome 19q13.2. NYD-SP8 encodes a 27 kD GPI-anchored cell surface protein, which shows structural h...
متن کاملProteases, extracellular matrix, and cancer: a workshop of the path B study section.
The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interac...
متن کاملFunctions of the extracellular matrix and matrix degrading proteases during tumor progression.
Cell interactions with extracellular matrices are important to pathological changes that occur during cell transformation and tumorigenesis. Several extracellular matrix proteins including fibronectin, thrombospondin-1, laminin, SPARC, and osteopontin have been suggested to modulate tumor phenotype by affecting cell migration, survival, or angiogenesis. Likewise, proteases including the matrix ...
متن کاملMatrix Proteases and the Degradome
Proteases are defined as enzymes that have the ability to perform the hydrolysis of peptide bonds. Owing to this characteristic, proteases were initially described as nonspecific enzymes of protein catabolism, participating in processes such as tissue destruction or degradation of dietary proteins. More recently, a better understanding of their functions has allowed consideration of proteases a...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2004
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63200-2